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上海信裕生物科技有限公司
TORC1抗体

TORC1抗体

商家询价

产品名称： TORC1抗体

英文名称： TORC1Antibody

产品编号： XY 10441-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 TORC1抗体Applications

In-house applications ELISA, WB, IP     Application not tested? Please see our Guarantee.
Published applications IF Publications 2 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Rat
Images
Prev1NextView more validation data
  • 10441-1-AP;mouse kidney tissuemouse kidney tissue were subjected to SDS PAGE followed by western blot with 10441-1-AP(TORC1 antibody) at dilution of 1:800
  • 10441-1-AP;mouse kidney tissueIP Result of anti-TORC1 (IP:10441-1-AP, 4ug; Detection:10441-1-AP 1:800) with mouse kidney tissue lysate 4000ug.
Positive WB detected in Mouse kidney tissue, A431 cells, Jurkat cells, L02 cells, mouse brain tissue
Positive IP detected in Mouse kidney tissue
Recommended dilution WB : 1:200-1:2000
IP : 1:200-1:2000
 TORC1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information TORC1抗体
Immunogen TORC1 fusion protein ag0693 Full name CREB regulated transcription coactivator 1
Calculated molecular
weight		 75 kDa Observed molecular 
weight		 75 kDa
GenBank accession 
number		 BC028050 Gene ID (NCBI) 23373
Gene symbol CRTC1 Synonyms CRTC1, FLJ14027, KIAA0616, MECT1, TORC 1, TORC1, Transducer of CREB protein 1, WAMTP1
Background TORC1抗体

CRTC1, also named as MECT1, TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. CRTC1 is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, CRTC1 involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. It may be required for dendritic growth of developing cortical neurons. This is a rabbit polyclonal antibody raised against residues near N terminus of human CRTC1. TORC1抗体

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