ANTXR1 Peptide
产品名称： ANTXR1 Peptide
英文名称： ANTXR1 Peptide
产品编号： P2796
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ANTXR1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y382 of human ANTXR1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.
Werner E, Kowalczyk AP, Faundez V.J Biol Chem. 2006 Aug 11;281(32):23227-36. Epub 2006 Jun 8.
- 2.
- The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin.
Wei W, Lu Q, Chaudry GJ, Leppla SH, Cohen SN.Cell. 2006 Mar 24;124(6):1141-54.
- 3.
- Receptor-specific requirements for anthrax toxin delivery into cells.
Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA.Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83. Epub 2005 Sep 1.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ANTXR1 polyclonal antibody (Cat # PAB3943) in HeLa cell line lysates (35 ug/lane). ANTXR1 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinomareacted with ANTXR1 polyclonal antibody (Cat # PAB3943), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 84168
- Protein Accession#:
- NP_115584;Q9H6X2
- Gene Name:
- ANTXR1
- Gene Alias:
- ATR,FLJ10601,FLJ11298,FLJ21776,TEM8
- Gene Description:
- anthrax toxin receptor 1
- Omim ID:
- 606410
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
- Other Designations:
- 2310008J16Rik,2810405N18Rik,tumor endothelial marker 8