AR monoclonal antibody, clone 2F12-抗体-抗体-生物在线

产品名称： AR monoclonal antibody, clone 2F12

英文名称： AR monoclonal antibody, clone 2F12

产品编号： MAB9566

产品价格： null

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围：

亚诺法生技股份有限公司（Abnova)

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Immunogen:
Recombinant protein corresponding to 321 amino acids near N-terminus of human AR.

Storage Instruction:
Store at 4°C on dry atmosphere.
After reconstitution with steril distilled water, Store at 4°C for at least two months.
For long term storage store at -20°C or below.
Aliquot to avoid repeated freezing and thawing.

Recommend Usage:
Immunohistochemistry (1:25)
The optimal working dilution should be determined by the end user.

Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining for paraffin-embedded human prostatic adenocarcinoma section using AR monoclonal antibody, clone 2F12 (Cat # MAB9566). Note nuclear staining of tumor cells.

Gene Summary:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq