CK II beta,丝/苏氨酸蛋白激酶II β抗体

产品编号HZ-2937R
英文名称CK II beta
中文名称丝/苏氨酸蛋白激酶II β抗体(casein kinase IIβ)
别 名Casein kinase 2 beta polypeptide; casein kinase IIβ; Casein kinase II subunit beta; CK II beta; CK2B; CK2N; CSK2B; CSK2B_HUMAN; CSNK 2B; CSNK2B; G5A; MGC138222; MGC138224; Phosvitin; Protein G5a.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 干细胞 细胞周期蛋白 转录调节因子 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow,
CK II beta,丝/苏氨酸蛋白激酶II β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CK II beta
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CK II beta,丝/苏氨酸蛋白激酶II β抗体PubMedPubMed
产品介绍background:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008].

Function:
Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Subunit:
Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2.

Post-translational modifications:
Phosphorylated by alpha subunit.

Similarity:
Belongs to the casein kinase 2 subunit beta family.

Gene ID:
1460

CK II beta,丝/苏氨酸蛋白激酶II β抗体Database links:
Entrez Gene: 1460 Human
Entrez Gene: 13001 Mouse
Entrez Gene: 81650 Rat
Omim: 115441 Human
SwissProt: P67870 Human
SwissProt: P67871 Mouse
SwissProt: P67874 Rat
Unigene: 73527 Human
Unigene: 378901 Mouse
Unigene: 137692 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.