FITC标记的整合素样金属蛋白酶与凝血酶样3蛋白抗体
产品名称： FITC标记的整合素样金属蛋白酶与凝血酶样3蛋白抗体
英文名称： Anti-ADAMTSL3/FITC
产品编号： HZ-5863R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ADAMTSL3/FITC Conjugated antibody
FITC标记的整合素样金属蛋白酶与凝血酶样3蛋白抗体
| 英文名称Anti-ADAMTSL3/FITC中文名称FITC标记的整合素样金属蛋白酶与凝血酶样3蛋白抗体别 名ADAMTS-like protein 3; ADAMTSL-3; ADAMTSL3; ATL3_HUMAN; Punctin-2. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域肿瘤 细胞生物 免疫学 信号转导 细胞粘附分子 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Dog, Pig, Horse, 产品应用IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量186kDa性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human ADAMTSL3亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. Post-translational modifications: Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 PLAC domain. Contains 10 TSP type-1 domains. Database links: UniProtKB/Swiss-Prot: P82987.4 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞外基质蛋白 |
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在结肠、输卵管、皮肤、乳腺、前列腺、附睾、肝脏、胰岛和胆管中，以及血管内皮细胞、平滑肌细胞、成纤维细胞、皮层和神经节细胞和心肌细胞中表达。也可由结肠癌、乳腺癌、前列腺癌、肾和皮肤肿瘤中的恶性上皮细胞表达。与正常结肠相比，结肠癌的表达显著减少。