FITC标记的细胞角蛋白4抗体
产品名称： FITC标记的细胞角蛋白4抗体
英文名称： Anti-Cytokeratin 4/FITC
产品编号： HZ-1006R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Cytokeratin 4/FITC Conjugated antibody
FITC标记的细胞角蛋白4抗体
| 英文名称 | Anti-Cytokeratin 4/FITC |
| 中文名称 | FITC标记的细胞角蛋白4抗体 |
| 别 名 | CK 4; CK4; CYK 4; CK-4; CYK4; Cytokeratin4; Cytokeratin 4; Cytokeratin-4; FLJ31692; K4; Keratin 4; Keratin-4; Keratin type II cytoskeletal 4; Keratin4; KRT 4; KRT4; K2C4_HUMAN; Keratin, type II cytoskeletal 4; K4; Type-II keratin Kb4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 信号转导 上皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CK4 C-terminus |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] Subunit: Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Tissue Specificity: Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. DISEASE: Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 3851 Human Omim: 123940 Human SwissProt: P19013 Human Unigene: 654610 Human Unigene: 706527 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 结构蛋白（Structural Proteins） 细胞角蛋白是一类与结构相关的蛋白家族，他们在上皮细胞中形成了细胞骨架中间丝。角蛋白在上皮细胞中往往成对存在，具有组织和细胞特异性。存在于口腔黏膜、鼻腔、食道和肛门生殖器上皮中的特异角蛋白为CK4和CK13。CK4是II型角蛋白，普遍存在于非角质化的鳞状上皮细胞中，CK4表达于基底细胞，也表达于鳞状细胞癌 |
由该基因编码的蛋白是角蛋白基因家族的成员。II型细胞角蛋白由碱性或中性蛋白组成，它们排列成对异型角蛋白链，在简单和分层的上皮组织的分化过程中共表达。这种II型细胞角蛋白特异表达于具有家族成员KRT13的粘膜和食管上皮的分化层中。这些基因的突变与白色海绵痣有关，以口腔、食道和肛门白斑为特征。II型细胞角蛋白聚集在染色体12q12～q13的一个区域。[ RefSeq，JUL 2008 ]